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Jumat, 26 Desember 2008

Web 2.0

Web 2.0 is an application that can provide office applications, video processing, table calculations, and various other applications so that it does not need to install the programs in your PC. 

The definition of social media in the context of Web 2.0 applications is a vessel that can mngerjakan content or activity in the same virtual world, so the application can be combined based on ideas of each individual 
So that the application or program can be resolved correctly, and can benefit all parties 

The difference between the concept of Web 1.0 and Web 2.0 is 

Web 1.0 is the Internet that is 1 in the direction and content of initialization. The provider provides content and media via the Internet and users access and use. 

Web 2.0 is the opposite of web 1.0, then penggunalah that provide more content. The provider only provides media applications such as Internet and the user will fill in the content and is used and accessed by other users.

Profits and losses e commerce

Benefits t e-commerce: 
- Revenue streams (revenue stream) is more promising. 
- Exposure can increase the market (market share) 
- Lower operational costs (operating cost) 
- Widen the coverage of (global reach) 
- Increase customer loyality 
- Improve supplier management 
- Cut production time 
- Increase the value chain (chain of income) 

loss e-Commerce: 
- Terms of financial loss directly due to cheating 
- Theft of valuable information 
- Lost business opportunities because of interference 
- Use of access to resources by parties that do not have the right 
- Loss of trust in the consumer

Selasa, 23 Desember 2008

Behind Soft ice cream

Literature ice cream will be Visible to the softness and yummy Taste. To make and store ice cream so yummy Taste and tenderness he Maintained, is the key Chemical. Without a solution koligatif nature or attributes may not colloidal delicious ice cream can be produced. 

The structure and content of ice cream 
Ice cream is not another form of yeast (dispersi gas in liquid) that preserved by cooling. Although the ice cream appears to exist as a solid, if viewed with the microscope will appear to be any of the four components, namely pad at globula fat milk, water (the size is not larger than 0.1 mm), Crystal-small ice crystals , And the water dissolves yes, salt, milk and protein. 
Various standards of food products in the world allow inflate the ice cream mixture with water to be twice the volume (called the maximum 100 percent overrun). Ice cream with the content of the water will feel more and more liquid, warmer, so do not feel eaten. 
When the fat content of milk is too low, the ice will make great and the coarser texture and feel cold. Emulsifier and stabilizer can cover the attributes that caused the lack of bad fat milk and can Taste sticky. 
Equipment Manufacturer of ice cream 
Nancy Johnson of Philadelphia is the first tool to create ice cream. Tools that it is created from wood bucket in which there is a smaller Vessel from the metal. Metal container can be Played using a pedal. In the space between the container and a small Wooden bucket filled with a mixture of ice and salt. Tools of the modern time, it still uses the same Principles . 
Making ice cream is actually just a simple, namely, the compound materials, and then cold. Pure water pressure in the atmosphere will coagulate 1 on the temperature 00 C. However, when the Substances are dissolved in water, the freezing point of water will Decrease. So, to Freeze the dough ice cream also requires temperatures below 00 C. For the dough ice cream included in the metal container, and then in the space between the Wooden Buckets and inserted a metal container of ice. 
Initially, the ice temperature will be less than 00 C (try to check this by measuring the temperature of the ice out of the Refrigerator). However, the surfaces of ice directly contact with the water temperatures will soon reach Rise 00 C, and some will melt. Temperature of the mixture of ice and water will be fixed overnight 00 C for not all ice melt. As mentioned above, clearly a mixture of ice cream does not coagulate in the temperature of 00 C koligatif nature of the Decline due to the freezing point. 

When you spreads a little salt to the mixture of ice and water before, we get a different matter. Discharge of ice water with salt dissolves Immediately will be that we add. Thus, the ice crystals will be floating in the Saline solution. Because the salt solution will have a freezing point lower than 00 C, ice will drop temperatures to the freezing point is reached salt water. In other words, a mixture of ice cream was surrounded by a Saline solution that the temperature lower than 00 C dough ice cream so that it will be frostbitten. 
But, whoa! If the mixture is only left alone will not Freeze ice cream produced, but dense cloud of meetings and contains a Crystal-Crystal of ice that will not be good if eaten. When you want good ice cream in the mouth, during the freezing process was used, the dough must be unstable. Stirring the mixture or shuffle during the freezing process is key in making the ice cream is good. 

The process aims to double this unstable. First, to understate the size of ice crystals that formed; the small size of the Crystal ice, the soft ice cream is formed. Second, the process will occur mixing water into the dough ice cream. Bubbles, bubbles of water mixed into the dough is yeast produce a uniform (homogeneous). 

Role emulsifier 
Stirring and simple method of cooling the same time this was a cause other problems. Basic Cream Transfer of a small globula fat suspension in the water. Globula-globula not join each other because each is surrounded by a membrane protein attract water, the water and make each globula keep stray. Stirring will damage the membrane proteins that make globula fat then can draw on each other. As a result, the cream will Rise to the surface. This is intended to be made when the Butter or oil, but clearly does not want to be made when the ice cream. 
Resolution simplest is to add emulsifier in the mixture. Molecular emulsifier will replace the membrane protein, one molecule end will drag in the water, while one end will solve the fat. Lecitin, a molecule found in the yellow eggs, emulsifier is a simple example. Therefore, one of the materials to make ice cream is yellow. In addition, it can be used in mono-or-gliserida or polisorbat that can dispersi globula fat more effectively. 
Can be made in the shell Vessel 
Because of the Principles of making it a very simple, so there is never funny Incident in the making of ice cream. The United States Air Force pilots during World War II (at the time of the Battlefield of hard to get ice cream) to make creative use of ice cream container with Cannon! The flight is to observe and get a gun that appeared to have the container temperature and vibration absorption spectrophotometer that are suitable to produce ice cream. So, every time they go Attack of the opponent, not forget they put a big container containing the dough ice cream. The result in the return trip from the Attack they will be able to enjoy a tasty ice cream. 

Storage of ice cream 
When ice cream is not Stored properly, some ice cream melt the ice crystals will form a larger, and when added back to the cooling of the ice crystals will GROW Belly. This will lead to a more coarse texture and uncomfortable in the mouth. In addition, the actual texture Rough this can also result because laktosa (milk) and will Crystals solution of the difficult and protracted return. 
To overcome this, when you finish eating (before the store again), can spreads a little looks or cellulose powder in the ice cream. Powder-powder will absorb the strong melt water, so the formation of ice crystals that can be prevented.

Minggu, 14 Desember 2008

DIGITAL SYSTEM

Analog is a way to present the quantity of physical (temperature or speed) with a continuous flow or voltage proportional 

Digital is a way to present the physical quantity of aligning with the binary number. Continuous relationship that is smooth 

Discrete is the separation of the segments or the different. 

GERBANG LOGIKA electronics chain is used to apply the basic logic of equality

Kamis, 11 Desember 2008

Lemak Dalam Makanan

Manfaat pembekalan berterusan vitamin C 

KAJIAN Journal Epidemiologi (Mei, 1992) menunjukkan individu yang tinggi kandungan vitamin C dalam darah hidup enam tahun lebih lama 
berbanding mereka yang 
sebaliknya. Kandungan vitamin C dalam pemakanan harian rakyat Malaysia sangat rendah. Sebagai contoh, sepinggan mi goreng dan nasi 
lemak hanya membekalkan 
1.7mg dan 0.9mg vitamin C. 

Vitamin C juga dikenali sebagai asid askorbik, ialah sejenis vitamin larut air. Ia adalah nutrien yang penting kerana badan tidak 
dapat menghasilkannya. 
Ini disebabkan manusia tidak memiliki enzim L-gulano gamma lakton oksida, yang menukarkan glukosa kepada asid askorbik. 

Sebenarnya, ketidakupayaan manusia menukarkan gula kepada vitamin C meningkatkan kecenderungan jangkitan penyakit diabetes jenis II 
kerana gula yang berlebihan 
dalam darah tidak dapat ditukar kepada vitamin C dan sebaliknya dikumpul dalam darah. Kebanyakan haiwan dan tumbuhan terutama alga 
dapat menghasilkan vitamin 
C. 

Vitamin C adalah vitamin yang paling tidak stabil, keberkesanannya akan berkurang melalui pendedahan matahari, haba dan udara. Oleh 
itu, kita selalu dinasihatkan 
supaya makan makanan yang kaya dengan vitamin C sebaik saja dipotong. 

Kira-kira 90 peratus vitamin C dalam pemakanan harian datang daripada buah-buahan dan sayur-sayuran, termasuklah brokoli, strawberi, 
oren, cili benggala, 
kubis, tembikai susu, lobak merah, bayam dan jambu batu. 

Fungsi utama vitamin C ialah menjaga kolagen, sejenis protein yang diperlukan untuk membentuk tisu penghubung dalam kulit, ligamen 
dan tulang. Ia penting 
untuk membentuk gigi dan gusi yang sihat, membantu penyerapan zat besi, menggalakkan penyembuhan luka dan membantu sistem keimunan 
tubuh. 

Vitamin C juga dikenali sebagai 'vitamin stres', kerana ia cepat habis digunakan apabila seseorang dalam situasi tertekan. Vitamin C 
adalah antioksida 
larut air yang membantu meneutralkan radikal bebas dalam badan. 

Vitamin C melindungi molekul penting dalam badan seperti protein, lipid (lemak), karbohidrat, DNA dan RNA daripada kerosakan radikal 
bebas akibat daripada 
pendedahan kepada toksin dan bahan pencemar. 

Golongan yang sering mengalami kekurangan vitamin C termasuklah perokok, mengambil alkohol secara berlebihan, cirit-birit, demam, 
jangkitan berpanjangan, 
tiroid terlalu aktif (hipertiroid), ulser perut, tuberkulosis (TB), bayi yang mengambil susu formula serta mereka yang menjalani 
pembedahan. 

Stres dan nikotin dalam rokok meningkatkan keperluan tubuh terhadap vitamin C. Mereka memerlukan sekurang-kurangnya 2,000mg vitamin 
C setiap hari. 

Tanda kekurangan vitamin C termasuklah gusi berdarah, enamel gigi yang lemah, mudah lebam, sakit sendi, anemia dan penembuhan luka 
yang lambat. 

Vitamin C adalah tidak stabil dan senang disingkirkan daripada badan. Oleh itu, badan mungkin tidak dapat menyerapkan semua vitamin 
C yang diambil walaupun 
dos pengambilan adalah tinggi. 

Pemilihan vitamin C yang bersesuaian adalah penting untuk memastikan makanan tambahan yang diambil betul-betul dapat memanfaatkan 
kesihatan. Pelbagai jenis 
vitamin C di pasaran mungkin merunsingkan anda. Yang mana satukah yang paling berkesan? 

TIP: Pengambilan vitamin C 

Pilih makanan tambahan vitamin C yang berkepekatan tinggi 

Kajian menunjukkan pengambilan makanan tambahan vitamin sebanyak 1g atau lebih setiap hari dapat meringan gejala selsema dan demam 
dan memendekkan tempoh 
penyembuhan. 

Pilih makanan tambahan vitamin C yang membekalkan vitamin secara berterusan (sustain release) 

Makanan tambahan vitamin C yang dihasilkan melalui teknologi sustain release dapat membekalkan vitamin C pada dos yang tertentu 
dalam sesuatu tempoh masa 
supaya semua nutrien yang diambil dapat diserap oleh sel. 

Rabu, 10 Desember 2008

Pengertian Blog

Menurut isinya blog berisikan kumpulan diary/ catan dari seseorang,dan jika dilihat dari sifatnya yang mudah untuk dimodifikasi.
oleh sebab itu blog menjadi salah satu pilihan orang untuk memposting tulisan ataupun informasi dari sebuah blog

Kamis, 27 November 2008

What?

If you have money or love,
what do you answer??
why?

Rabu, 26 November 2008

Facebook and Twitter and friends

People keeps comparing those services.
I don’t get it. They’re completely different. Twitter is an open conversation and a place where you meet new friends. Facebook is a closed conversation and a place where you meet old friends.
I just did a quick count. On twitter I follow 299 people. And 37 of them are friends to the level that I would have said hello if I met them on the street. On Facebook 151 of my 200 friends are at the same level.
That said. Currently I rarely visit Facebook. And I use Twitter all day long.

Senin, 24 November 2008

Technology

By the mid 20th century, humans had achieved a mastery of technology sufficient to leave the surface of the Earth for the first time and explore space.
Technology is a broad concept that deals with a species' usage and knowledge of tools and crafts, and how it affects a species' ability to control and adapt to its environment. Technology is a term with origins in the Greek "technologia", "τεχνολογία" — "techne", "τέχνη" ("craft") and "logia", "λογία" ("saying").[1] However, a strict definition is elusive; "technology" can refer to material objects of use to humanity, such as machines, hardware or utensils, but can also encompass broader themes, including systems, methods of organization, and techniques. The term can either be applied generally or to specific areas: examples include "construction technology", "medical technology", or "state-of-the-art technology".
The human race's use of technology began with the conversion of natural resources into simple tools. The prehistorical discovery of the ability to control fire increased the available sources of food and the invention of the wheel helped humans in travelling in and controlling their environment. Recent technological developments, including the printing press, the telephone, and the Internet, have lessened physical barriers to communication and allowed humans to interact on a global scale. However, not all technology has been used for peaceful purposes; the development of weapons of ever-increasing destructive power has progressed throughout history, from clubs to nuclear weapons.
Technology has affected society and its surroundings in a number of ways. In many societies, technology has helped develop more advanced economies (including today's global economy) and has allowed the rise of a leisure class. Many technological processes produce unwanted by-products, known as pollution, and deplete natural resources, to the detriment of the Earth and its environment. Various implementations of technology influence the values of a society and new technology often raises new ethical questions. Examples include the rise of the notion of efficiency in terms of human productivity, a term originally applied only to machines, and the challenge of traditional norms.
Philosophical debates have arisen over the present and future use of technology in society, with disagreements over whether technology improves the human condition or worsens it. Neo-Luddism, anarcho-primitivism, and similar movements criticise the pervasiveness of technology in the modern world, claiming that it harms the environment and alienates people; proponents of ideologies such as transhumanism and techno-progressivism view continued technological progress as beneficial to society and the human condition. Indeed, until recently, it was believed that the development of technology was restricted only to human beings, but recent scientific studies indicate that other primates and certain dolphin communities have developed simple tools and learned to pass their knowledge to other generations.
Contents[hide]
1 Definition and usage
2 Science, engineering and technology
3 Role in human history
3.1 Paleolithic (2.5 million – 10,000 BC)
3.1.1 Stone tools
3.1.2 Fire
3.1.3 Clothing and shelter
3.2 Neolithic through Classical Antiquity (10,000BCE – 300CE)
3.2.1 Metal tools
3.2.2 Energy and Transport
3.3 Modern history (0CE —)
4 Technology and philosophy
4.1 Technicism
4.2 Optimism
4.3 Pessimism
4.4 Appropriate technology
5 Other species
6 See also
6.1 Theories and concepts in technology
6.2 Economics of technology
7 Notes
8 References
9 External links
10 Further reading
//

Definition and usage

The invention of the printing press made it possible for scientists and politicians to communicate their ideas with ease, leading to the Age of Enlightenment; an example of technology as a cultural force.
In general technology is the relationship that society has with its tools and crafts, and to what extent society can control its environment. The Merriam-Webster dictionary offers a definition of the term: "the practical application of knowledge especially in a particular area" and "a capability given by the practical application of knowledge".[1] Ursula Franklin, in her 1989 "Real World of Technology" lecture, gave another definition of the concept; it is "practice, the way we do things around here".[2] The term is often used to imply a specific field of technology, or to refer to high technology or just consumer electronics, rather than technology as a whole.[3] Bernard Stiegler, in Technics and Time, 1, defines technology in two ways: as "the pursuit of life by means other than life", and as "organized inorganic matter."[4]
Technology can be most broadly defined as the entities, both material and immaterial, created by the application of mental and physical effort in order to achieve some value. In this usage, technology refers to tools and machines that may be used to solve real-world problems. It is a far-reaching term that may include simple tools, such as a crowbar or wooden spoon, or more complex machines, such as a space station or particle accelerator. Tools and machines need not be material; virtual technology, such as computer software and business methods, fall under this definition of technology.[5]
The word "technology" can also be used to refer to a collection of techniques. In this context, it is the current state of humanity's knowledge of how to combine resources to produce desired products, to solve problems, fulfill needs, or satisfy wants; it includes technical methods, skills, processes, techniques, tools and raw materials. When combined with another term, such as "medical technology" or "space technology", it refers to the state of the respective field's knowledge and tools. "State-of-the-art technology" refers to the high technology available to humanity in any field.
Technology can be viewed as an activity that forms or changes culture.[6] Additionally, technology is the application of math, science, and the arts for the benefit of life as it is known. A modern example is the rise of communication technology, which has lessened barriers to human interaction and, as a result, has helped spawn new subcultures; the rise of cyberculture has, at its basis, the development of the Internet and the computer.[7] Not all technology enhances culture in a creative way; technology can also help facilitate political oppression and war via tools such as guns. As a cultural activity, technology predates both science and engineering, each of which formalize some aspects of technological endeavor.

Science, engineering and technology
The distinction between science, engineering and technology is not always clear. Science is the reasoned investigation or study of phenomena, aimed at discovering enduring principles among elements of the phenomenal world by employing formal techniques such as the scientific method.[8] Technologies are not usually exclusively products of science, because they have to satisfy requirements such as utility, usability and safety.
Engineering is the goal-oriented process of designing and making tools and systems to exploit natural phenomena for practical human means, often (but not always) using results and techniques from science. The development of technology may draw upon many fields of knowledge, including scientific, engineering, mathematical, linguistic, and historical knowledge, to achieve some practical result.
Technology is often a consequence of science and engineering — although technology as a human activity precedes the two fields. For example, science might study the flow of electrons in electrical conductors, by using already-existing tools and knowledge. This new-found knowledge may then be used by engineers to create new tools and machines, such as semiconductors, computers, and other forms of advanced technology. In this sense, scientists and engineers may both be considered technologists; the three fields are often considered as one for the purposes of research and reference.[9]
The exact relations between science and technology in particular have been debated by scientists, historians, and policymakers in the late 20th century, in part because the debate can inform the funding of basic and applied science. In immediate wake of World War II, for example, in the United States it was widely considered that technology was simply "applied science" and that to fund basic science was to reap technological results in due time. An articulation of this philosophy could be found explicitly in Vannevar Bush's treatise on postwar science policy, Science—The Endless Frontier: "New products, new industries, and more jobs require continuous additions to knowledge of the laws of nature... This essential new knowledge can be obtained only through basic scientific research." In the late-1960s, however, this view came under direct attack, leading towards initiatives to fund science for specific tasks (initiatives resisted by the scientific community). The issue remains contentious—though most analysts resist the model that technology simply is a result of scientific research.[10][11]

Role in human history
Main articles: History of technology and Timeline of invention

Paleolithic (2.5 million – 10,000 BC)

A primitive chopper
The use of tools by early humans was partly a process of discovery, partly of evolution. Early humans evolved from a race of foraging hominids which were already bipedal,[12] with a brain mass approximately one third that of modern humans.[13] Tool use remained relatively unchanged for most of early human history, but approximately 50,000 years ago, a complex set of behaviors and tool use emerged, believed by many archaeologists to be connected to the emergence of fully-modern language.[14]

Stone tools

Hand axes from the Acheulian period

A Clovis point, made via pressure flaking
Human ancestors have been using stone and other tools since long before the emergence of Homo sapiens approximately 200,000 years ago.[15] The earliest methods of stone tool making, known as the Oldowan "industry", date back to at least 2.3 million years ago,[16] with the earliest direct evidence of tool usage found in Ethiopia within the Great Rift Valley, dating back to 2.5 million years ago.[17] This era of stone tool use is called the Paleolithic, or "Old stone age", and spans all of human history up to the development of agriculture approximately 12,000 years ago.
To make a stone tool, a "core" of hard stone with specific flaking properties (such as flint) was struck with a hammerstone. This flaking produced a sharp edge on the core stone as well as on the flakes, either of which could be used as tools, primarily in the form of choppers or scrapers.[18] These tools greatly aided the early humans in their hunter-gatherer lifestyle to perform a variety of tasks including butchering carcasses (and breaking bones to get at the marrow); chopping wood; cracking open nuts; skinning an animal for its hide; and even forming other tools out of softer materials such as bone and wood.[19]
The earliest stone tools were crude, being little more than a fractured rock. In the Acheulian era, beginning approximately 1.65 million years ago, methods of working these stone into specific shapes, such as hand axes emerged. The Middle Paleolithic, approximately 300,000 years ago, saw the introduction of the prepared-core technique, where multiple blades could be rapidly formed from a single core stone.[18] The Upper Paleolithic, beginning approximately 40,000 years ago, saw the introduction of pressure flaking, where a wood, bone, or antler punch could be used to shape a stone very finely.[20]

Fire
The discovery and utilization of fire, a simple energy source with many profound uses, was a turning point in the technological evolution of humankind.[21] The exact date of its discovery is not known; evidence of burnt animal bones at the Cradle of Humankind suggests that the domestication of fire occurred before 1,000,000 BCE;[22] scholarly consensus indicates that Homo erectus had controlled fire by between 500,000 BCE and 400,000 BCE.[23][24] Fire, fueled with wood and charcoal, allowed early humans to cook their food to increase its digestibility, improving its nutrient value and broadening the number of foods that could be eaten.[25]

Clothing and shelter
Other technological advances made during the Paleolithic era were clothing and shelter; the adoption of both technologies cannot be dated exactly, but they were a key to humanity's progress. As the Paleolithic era progressed, dwellings became more sophisticated and more elaborate; as early as 380,000 BCE, humans were constructing temporary wood huts.[26][27] Clothing, adapted from the fur and hides of hunted animals, helped humanity expand into colder regions; humans began to migrate out of Africa by 200,000 BCE and into other continents, such as Eurasia.[28]
Humans began to work bones, antler, and hides, as evidenced by burins and racloirs produced during this period.[citation needed]

Neolithic through Classical Antiquity (10,000BCE – 300CE)

An array of Neolithic artifacts, including bracelets, axe heads, chisels, and polishing tools.
Man's technological ascent began in earnest in what is known as the Neolithic period ("New stone age"). The invention of polished stone axes was a major advance because it allowed forest clearance on a large scale to create farms. The discovery of agriculture allowed for the feeding of larger populations, and the transition to a sedentist lifestyle increased the number of children that could be simultaneously raised, as young children no longer needed to be carried, as was the case with the nomadic lifestyle. Additionally, children could contribute labor to the raising of crops more readily than they could to the hunter-gatherer lifestyle.[29][30]
With this increase in population and availability of labor came an increase in labor specialization.[31] What triggered the progression from early Neolithic villages to the first cities, such as Uruk, and the first civilizations, such as Sumer, is not specifically known; however, the emergence of increasingly hierarchical social structures, the specialization of labor, trade and war amongst adjacent cultures, and the need for collective action to overcome environmental challenges, such as the building of dikes and reservoirs, are all thought to have played a role.[32]

Metal tools
Continuing improvements led to the furnace and bellows and provided the ability to smelt and forge native metals (naturally occurring in relatively pure form).[33] Gold, copper, silver, and lead, were such early metals. The advantages of copper tools over stone, bone, and wooden tools were quickly apparent to early humans, and native copper was probably used from near the beginning of Neolithic times (about 8000 BCE).[34] Native copper does not naturally occur in large amounts, but copper ores are quite common and some of them produce metal easily when burned in wood or charcoal fires. Eventually, the working of metals led to the discovery of alloys such as bronze and brass (about 4000 BCE). The first uses of iron alloys such as steel dates to around 1400 BCE.

Energy and Transport
Meanwhile, humans were learning to harness other forms of energy. The earliest known use of wind power is the sailboat.[citation needed] The earliest record of a ship under sail is shown on an Egyptian pot dating back to 3200 BCE.[citation needed] From prehistoric times, Egyptians probably used "the power of the Nile" annual floods to irrigate their lands, gradually learning to regulate much of it through purposely-built irrigation channels and 'catch' basins. Similarly, the early peoples of Mesopotamia, the Sumerians, learned to use the Tigris and Euphrates rivers for much the same purposes. But more extensive use of wind and water (and even human) power required another invention.

The wheel was invented in circa 4000 BCE.
According to archaeologists, the wheel was invented around 4000 B.C. The wheel was likely independently invented in Mesopotamia (in present-day Iraq) as well. Estimates on when this may have occurred range from 5500 to 3000 B.C., with most experts putting it closer to 4000 B.C. The oldest artifacts with drawings that depict wheeled carts date from about 3000 B.C.; however, the wheel may have been in use for millennia before these drawings were made. There is also evidence from the same period of time that wheels were used for the production of pottery. (Note that the original potter's wheel was probably not a wheel, but rather an irregularly shaped slab of flat wood with a small hollowed or pierced area near the center and mounted on a peg driven into the earth. It would have been rotated by repeated tugs by the potter or his assistant.) More recently, the oldest-known wooden wheel in the world was found in the Ljubljana marshes of Slovenia.[35]
The invention of the wheel revolutionized activities as disparate as transportation, war, and the production of pottery (for which it may have been first used). It didn't take long to discover that wheeled wagons could be used to carry heavy loads and fast (rotary) potters' wheels enabled early mass production of pottery. But it was the use of the wheel as a transformer of energy (through water wheels, windmills, and even treadmills) that revolutionized the application of nonhuman power sources.

Modern history (0CE —)
Tools include both simple machines (such as the lever, the screw, and the pulley), and more complex machines (such as the clock, the engine, the electric generator and the electric motor, the computer, radio, and the Space Station, among many others). As tools increase in complexity, so does the type of knowledge needed to support them. Complex modern machines require libraries of written technical manuals of collected information that has continually increased and improved — their designers, builders, maintainers, and users often require the mastery of decades of sophisticated general and specific training. Moreover, these tools have become so complex that a comprehensive infrastructure of technical knowledge-based lesser tools, processes and practices (complex tools in themselves) exist to support them, including engineering, medicine, and computer science. Complex manufacturing and construction techniques and organizations are needed to construct and maintain them. Entire industries have arisen to support and develop succeeding generations of increasingly more complex tools. The relationship of technology with society ( culture) is generally characterized as synergistic, symbiotic, co-dependent, co-influential, and co-producing, i.e. technology and society depend heavily one upon the other (technology upon culture, and culture upon technology). It is also generally believed that this synergistic relationship first occurred at the dawn of humankind with the invention of simple tools, and continues with modern technologies today. Today and throughout history, technology influences and is influenced by such societal issues/factors as economics, values, ethics, institutions, groups, the environment, government, among others. The discipline studying the impacts of science, technology, and society and vice versa is called Science and technology in society.

Technology and philosophy

Technicism
Generally, technicism is an over reliance or overconfidence in technology as a benefactor of society.
Taken to extreme, some argue that technicism is the belief that humanity will ultimately be able to control the entirety of existence using technology. In other words, human beings will someday be able to master all problems and possibly even control the future using technology. Some, such as Monsma,[36] connect these ideas to the abdication of religion as a higher moral authority.
More commonly, technicism is a criticism of the commonly held belief that newer, more recently-developed technology is "better."[citation needed] For example, more recently-developed computers are faster than older computers, and more recently-developed cars have greater gas efficiency and more features than older cars.[citation needed] Because current technologies are generally accepted as good, future technological developments are not considered circumspectly, resulting in what seems to be a blind acceptance of technological development.[citation needed]

Optimism
See also: Extropianism
Optimistic assumptions are made by proponents of ideologies such as transhumanism and singularitarianism, which view technological development as generally having beneficial effects for the society and the human condition. In these ideologies, technological development is morally good. Some critics see these ideologies as examples of scientism and techno-utopianism and fear the notion of human enhancement and technological singularity which they support. Some have described Karl Marx as a techno-optimist.[37]

Pessimism
See also: Luddite, Neo-luddism, Anarcho-Primitivism, and Bioconservatism
On the somewhat pessimistic side are certain philosophers like the Herbert Marcuse and John Zerzan, who believe that technological societies are inherently flawed a priori. They suggest that the result of such a society is to become evermore technological at the cost of freedom and psychological health (and probably physical health in general, as pollution from technological products is dispersed).
Many, such as the Luddites and prominent philosopher Martin Heidegger, hold serious reservations, although not a priori flawed reservations, about technology. Heidegger presents such a view in "The Question Concerning Technology": "Thus we shall never experience our relationship to the essence of technology so long as we merely conceive and push forward the technological, put up with it, or evade it. Everywhere we remain unfree and chained to technology, whether we passionately affirm or deny it."[38]
Some of the most poignant criticisms of technology are found in what are now considered to be dystopian literary classics, for example Aldous Huxley's Brave New World and other writings, Anthony Burgess's A Clockwork Orange, and George Orwell's Nineteen Eighty-Four. And, in Faust by Goethe, Faust's selling his soul to the devil in return for power over the physical world, is also often interpreted as a metaphor for the adoption of industrial technology.
An overtly anti-technological treatise is Industrial Society and Its Future, written by Theodore Kaczynski (aka The Unabomber) and printed in several major newspapers (and later books) as part of an effort to end his bombing campaign of the techno-industrial infrastructure.

Appropriate technology
See also: Technocriticism and Technorealism
The notion of appropriate technology, however, was developed in the 20th century (e.g., see the work of Jacques Ellul) to describe situations where it was not desirable to use very new technologies or those that required access to some centralized infrastructure or parts or skills imported from elsewhere. The eco-village movement emerged in part due to this concern.

Thrombocytopenia (reduced platelet count)

Thrombocytopenia (reduced platelet count)

Written by Dr Claire Harrison, Consultant Haematologist, St Thomas' Hospital, London and Professor Samuel Machin, Department of Haematology, University College London Hospital

What is thrombocytopenia?Thrombocytopenia is the term for a reduced platelet (thrombocyte) count. It happens when platelets are lost from the circulation faster than they can be replaced from the bone marrow where they are made.

Did you know?
All blood cells are created within the bone marrow.

Thrombocytopenia can result from:
a failure of platelet production
an increased rate of removal from blood.What are platelets?Platelets are tiny cells that circulate in the blood and whose function is to take part in the clotting process.Inside each platelet are many granules, containing compounds that enhance the ability of platelets to stick to each other and also to the surface of a damaged blood vessel wall.

Figure 1: Normal blood film
The platelet count in the circulating blood is normally between 150 and 400 million per millilitre of blood. Newborn babies have a slightly lower level, but are normally within the adult range by three months of age.Many factors can influence an individual's platelet count including exercise and racial origin. The average life span of a platelet in the blood is 10 days.What do platelets do?Platelets are essential in the formation of blood clots to prevent haemorrhage - bleeding from a ruptured blood vessel.An adequate number of normally functioning platelets is also needed to prevent leakage of red blood cells from apparently uninjured vessels.In the event of bleeding, muscles in the vessel wall contract and reduce blood flow. The platelets then stick to each other (aggregation) and hold on to the vessel wall (primary haemostasis). The coagulation factors are then activated, resulting in normally liquid blood becoming an insoluble clot or glue.What are the risks of a low platelet count? The main effect of a reduced platelet count is an increased risk of bleeding, but this rarely occurs until there are less than 80-100 million platelets per ml.There is not a close relationship between the number of platelets and the severity of bleeding, but there is an increasing risk of haemorrhage if platelet numbers fall or if platelet function is impaired (for example by aspirin, which reduces the 'stickiness' of the platelets).There is a particularly high risk of spontaneous bleeding once the platelet count drops below 10 million per ml. The bleeding is usually seen on the skin in the form of tiny pin-prick haemorrhages (purpura), or bruises (ecchymoses) following minor trauma.Bleeding from the nose and the gums is also quite common. More serious haemorrhage can occur at the back of the eye (retina), sometimes threatening sight.The most serious complication, which is potentially fatal, is spontaneous bleeding inside the head (intracranial) or from the lining of the gut (gastrointestinal).Types of thrombocytopeniaSpecific types of low platelet count include:
idiopathic thrombocytopenic purpura (ITP)
thrombotic thrombocytopenic purpura (TTP)
haemolytic uraemic syndrome. What causes a low platelet count?The many different causes of thrombocytopenia are detailed below. These causes are not mutually exclusive and more than one may be responsible for an abnormal platelet count.

Causes summary
False thrombocytopenia
Clot in the sample.
Platelets clumped.
Congenital thrombocytopenia
Rare inherited disorders (eg May Hegglin anomaly, Bernard Soulier syndrome).
Defective platelet production
Bone marrow aplasia (failure).
Metabolic disorders, eg kidney failure, alcohol.
Abnormal platelet precursors: viral infections, inherited abnormalities.
Bone marrow infiltration, eg leukaemia, lymphoma.
Diminished platelet survival
Antibodies in response to drugs, blood transfusion or another disease, eg glandular fever, malaria.
Unknown cause (ITP).
Clotting disorder (DIC).
Blood disorder (TTP).
Loss of platelets from the circulation
Massive blood transfusion or exchange.
Enlarged spleen.

Artefactual (false) thrombocytopenia Some people have platelets that stick together due to the presence of proteins in the blood (antibodies) that bind to the platelets.These antibodies also bind to a chemical in blood that is tested in the lab, giving a falsely low platelet count. For this reason, it is helpful to repeat the sample in different tubes with different chemicals.The platelet count can also be reduced if the blood sample is difficult to take and the blood clots - thus using up some of the platelets.

Congenital thrombocytopeniaSeveral rare inherited diseases cause low platelet counts. The severity of the thrombocytopenia varies with the condition and also the individual patient.In some of these conditions, eg May Hegglin anomaly, bleeding doesn't happen often.In other inherited diseases, eg Bernard Soulier syndrome, the platelets function less well and lifelong bleeding symptoms can occur.

Defective platelet production Platelets are produced within the bone marrow from cells called megakaryocytes.If there is a problem in the bone marrow, for example due to abnormal cells, then the number of megakaryocytes will drop, lowering the number of platelets that can be produced.Examples of abnormal cells accumulating in the bone marrow include:
acute leukaemia where leukaemic cells, or 'blasts', are seen
other abnormal cancer cells such as lymphoma
more rarely, when cancers develop in another part of the body and have spread (metastasised) to the bone marrow.Alternatively, there may be something wrong with the platelet production process itself so not enough platelets are formed.Impaired platelet production can also be due to:
the side-effects of drugs such as chemotherapy (anti-cancer) agents
viral infections such as HIV
metabolic disorders such as shortage of vitamin B12 or folic acid, kidney failure, alcohol.
an abnormality of the bone marrow called myelodysplasia.Sometimes platelet production is defective because of an abnormality in the cells that make up the structural parts of the bone marrow, called the stroma. Examples include:
marble bone disease (osteopetrosis). This hereditary condition causes dense, brittle bones at the expense of bone marrow.

myelofibrosis. This causes a massive increase in the amount of fibrous tissue, which impairs platelet production as well as the production of other blood cells.
Diminished platelet survivalPlatelet numbers fall if they are removed from the circulation more rapidly than they are produced.Platelets are removed for several reasons. They may be coated with an antibody, or are clumped together and then removed.Antibodies that cause platelet removal can be due to:
infections such as HIV
medicines such as the anti-malaria drug quinine
a specific disease in which abnormal production of other antibodies may occur, eg rheumatoid arthritis, the skin disease systemic lupus erythematosis or the blood disease chronic lymphocytic leukaemia.These antibodies can also occur in someone who is otherwise completely well. This is called idiopathic thrombocytopinea (ITP) - literally, a low platelet count of unknown cause.Alternatively, the platelets may be used up if the blood clotting process is inappropriately 'switched on'. This condition is known as disseminated intravascular coagulation (DIC).DIC can result from the following:
in severe infections such as meningitis.
as a complication of pregnancy or labour, eg high blood pressure and pre-eclampsia
in some cancers, specifically types of acute myeloid leukaemia and prostate cancer
in some rare blood disorders such as thrombotic thrombocytopenic purpura or haemolytic uraemic syndrome (sometimes due to food poisoning outbreaks).
Loss of platelets from the circulation
Abnormal distribution of platelets: a low platelet count may be due to a build up of platelets outside the normal blood pool, for example in a patient with a very large spleen.
Dilution of platelets: the platelet count can fall when a patient is transfused with a large volume of red blood cells that do not contain platelets, because of dilution of normal blood factors.How is a low platelet count diagnosed?Investigation usually starts with a history of symptoms, signs of bleeding or bruising, other medical problems, recent infections and medications. A blood test is then taken.In the haematology lab the doctor:
performs a full blood count
examines the blood film under a microscope (see Figure 1)
examines the blood sample in the test tube.Usually, another full blood count sample is requested to confirm the result and see if it is a persisting abnormality.Depending upon the severity of the platelet lack and the likely cause, the person is likely to be referred to a haematologist at the hospital.If the platelet count is very low, the person may need to be seen on the same day, and have a bone marrow test performed.A bone marrow test is done under local anaesthetic, with samples usually taken from the back of the pelvis. This test helps the haematologist to decide if platelets are being produced normally and whether the rest of the bone marrow appears normal.Further tests such as genetic tests can also be done on a bone marrow sample.What treatment is available? The choice of treatment depends upon the severity of the platelet count, its cause and whether or not there is any bleeding.
Caution
In a type of thrombocytopenia called TTP, the use of platelet concentrates is hazardous.
If life-threatening bleeding occurs, eg to the head or bowel, urgent treatment is needed with platelet concentrates via blood transfusion.The effect of the concentrates is then monitored by measuring the platelet count and assessing any continuing bleeding.The management of acute bleeding also involves treatment of the underlying cause of the low platelets.If there is no major bleeding, treatment is aimed at the cause of the low platelet count.
Figure 2: A bag of platelets for transfusion
If a drug is thought to be the cause, it should be stopped, providing this is safe, and the platelet count monitored.
If an infection is suspected, treatment of it with antibiotics could be started.
For some infections, especially viral ones such as glandular fever, there is no specific treatment and close observation may be necessary.
When an infection results in a low platelet count by causing DIC, treatment tackles the underlying infection and the DIC. Blood components are used to replace the clotting factors and platelets.
If platelet production fails due to the presence of abnormal or malignant cells, treatment is directed at those abnormal cells - for example, chemotherapy or radiotherapy would be used in leukaemia. This can temporarily damage the bone marrow and worsen the thrombocytopenia. Transfusions would then be given if the platelet count becomes very low until it reaches a safer level or the bone marrow recovers.

Thrombocytopenia

Thrombocytopenia
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ThrombocytopeniaClassification and external resources
ICD-10
D69.6, P61.0
ICD-9
287.3, 287.4, 287.5
OMIM
188000 313900
DiseasesDB
27522
MedlinePlus
000586
MeSH
D013921

Thrombocytopenia (or -paenia, or thrombopenia in short) is the presence of relatively few platelets in blood.

Generally speaking, in humans, a normal platelet count ranges from 150,000 and 450,000 per mm3 (microlitre).[1] These limits, however, are determined by the 2.5th lower and upper percentile, and a deviation does not necessarily imply any form of disease. The number of platelets in a blood sample also decreases rather quickly with time and a low platelet count may be caused by a delay between sampling and analysis.
Contents[hide]
1 Signs and symptoms
2 Diagnosis
3 Causes
3.1 Decreased production
3.2 Increased destruction
3.3 Medication-induced
4 Treatment
4.1 Thrombotic thrombocytopenic purpura (TTP)
4.2 Idiopathic thrombocytopenic purpura (ITP)
4.3 Heparin-induced thrombocytopenia and thrombosis (HITT)
4.4 Congenital amegakaryocytic thrombocytopenia (CAMT)
5 References
6 External links
//

Signs and symptoms
Often, low platelet levels do not lead to clinical problems; rather, they are picked up on a routine full blood count (or CBC, complete blood count). Occasionally, there may be bruising, particularly purpura in the forearms, nosebleeds and/or bleeding gums.
It is vital that a full medical history is elicited, to ensure the low platelet count is not due to a secondary process. It is also important to ensure that the other blood cell types red blood cells, and white blood cells, are not also suppressed.

Diagnosis
Laboratory tests might include: full blood count, liver enzymes, renal function, vitamin B12 levels, folic acid levels, erythrocyte sedimentation rate, and peripheral blood smear.
If the cause for the low platelet count remains unclear, bone marrow biopsy is often undertaken, to differentiate whether the low platelet count is due to decreased production or peripheral destruction.

Causes
Decreased platelet counts can be due to a number of disease processes:

Decreased production
vitamin B12 or folic acid deficiency
leukemia or myelodysplastic syndrome
Decreased production of thrombopoietin by the liver in liver failure.
Sepsis, systemic viral or bacterial infection
Dengue fever can cause thrombocytopenia by direct infection of bone marrow megakaryocytes as well as immunological shortened platelet survival
Hereditary syndromes
Congenital Amegakaryocytic Thrombocytopenia (CAMT)
Thrombocytopenia absent radius syndrome
Fanconi anemia
Bernard-Soulier syndrome, associated with large platelets
May-Hegglin anomaly, the combination of thrombocytopenia, pale-blue leuckocyte inclusions, and giant platelets
Grey platelet syndrome
Alport syndrome

Increased destruction
idiopathic thrombocytopenic purpura (ITP)
thrombotic thrombocytopenic purpura (TTP)
hemolytic-uremic syndrome (HUS)
disseminated intravascular coagulation (DIC)
paroxysmal nocturnal hemoglobinuria (PNH)
antiphospholipid syndrome
systemic lupus erythematosus (SLE)
post transfusion purpura
neonatal alloimmune thrombocytopenia (NAITP)
Splenic sequestration of platelets due to hypersplenism
Dengue fever has been shown to cause shortened platelet survival and immunological platelet destruction
HIV Scaradavou A (2002). "HIV-related thrombocytopenia". Blood Rev. 16 (1): 73–6. doi:10.1054/blre.2001.0188. PMID 11914001, http://linkinghub.elsevier.com/retrieve/pii/S0268960X01901882.

Medication-induced
The most comprehensive list of thrombocytopenia-inducing medications is maintained by Dr. James George at Ohio State University at this website, though last updated in 2004. A small subset of drug-induced thrombocytopenia culprits:
Drug name
Heparin
Valproic acid
Quinidine
Abciximab
Sulfonamide antibiotics
Interferons
Measles-mumps-rubella vaccine
Glycoprotein IIb/IIIa inhibitors
Clopidogrel
Vancomycin [2][3]
Linezolid
Famotidine
Mebeverine
Tinidazole/Metronidazole
Direct myelosuppression
Valproic acid
Methotrexate
Carboplatin
Interferon
Other chemotherapy drugs
Immunological platelet destruction
Drug binds Fab portion of an antibody. The classic example of this mechanism is the quinidine group of drugs. The Fc portion of the antibody molecule is not involved in the binding process.
Drug binds to Fc, and drug-antibody complex binds and activates platelets. Heparin induced thrombocytopenia (HIT) is the classic example of this phenomenon. In HIT, the heparin-antibody-platelet factor 4 (PF4) complex binds to Fc receptors on the surface of the platelet. Since Fc portion of the antibody is bound to the platelets, they are not available to the Fc receptors of the reticulo-endothelial cells, so therefore this system cannot destroy platelets as usual. This may explain why severe thrombocytopenia is not a common feature of HIT.
Heparin-induced thrombocytopenia (HIT or white clot syndrome): this is a rare but serious condition that may occur in a hospitalized population. The most common clinical setting for HIT is in postoperative coronary artery bypass graft recipients, who may receive large quantities of heparin during surgery. HIT typically occurs about a week after exposure to heparin. The heparin-PF4 antibody complex will activate the platelets, and this can often lead to thrombosis. The term HITT, where the last T stands for thrombosis, denotes the concept that heparin-induced thrombocytopenia often is associated with thrombosis.

Treatment
Treatment is guided by etiology and disease severity. The main concept in treating thrombocytopenia is to eliminate the underlying problem, whether that means discontinuing suspected drugs that cause thrombocytopenia, or treating underlying sepsis. Diagnosis and treatment of serious thrombocytopenia is usually directed by a hematologist.
Specific treatment plans often depend on the underlying etiology of the thrombocytopenia.

Thrombotic thrombocytopenic purpura (TTP)
Treatment of thrombotic thrombocytopenic purpura is a medical emergency, since the hemolytic anemia and platelet activation can lead to renal failure and changes in the level of consciousness. Treatment of TTP was revolutionized in the 1980s with the application of plasmapheresis. According to the Furlan-Tsai hypothesis [4] [5] , this treatment theoretically works by removing antibodies directed against the von Willebrand factor cleaving protease, ADAMTS-13. The plasmapheresis procedure also adds active ADAMTS-13 protease proteins to the patient, restoring a more physiological state of von Willebrand factor multimers. Patients with persistent antibodies against ADAMTS-13 do not always manifest TTP, and these antibodies alone are not sufficient to explain the how plasmapheresis treats TTP.

Idiopathic thrombocytopenic purpura (ITP)
Main article: Idiopathic thrombocytopenic purpura
Many cases of ITP can be left untreated, and spontaneous remission (especially in children) is not uncommon. However, counts of under 50,000 are usually monitiored with regular blood tests, and those with counts of under 10,000 are usually treated, as the risk of serious spontaneous bleeding is high with a platelet count this low. Any patient experiencing severe bleeding symptoms is also usually treated. The threshold for treating ITP has decreased since the 1990s, and hematologists recognize that patients rarely spontaneously bleed with platelet counts greater than 10,000—though there are documented exceptions to this observation.
Treatments for ITP include:
Prednisone and other corticosteroids
Intravenous immune globulin
Splenectomy
Danazol
Rituximab
Romiplostim
Thrombopoetin analogues have been tested extensively for the treatment of ITP. These agents had previously shown promise but had been found to stimulate antibodies against endogenous thrombopoeitin or lead to thrombosis.
Romiplostim (trade name Nplate, formerly AMG 531) was found to be safe and effective for the treatment of ITP in refractory patients, especially those who relapsed following splenectomy.[6][7][8] Romiplostim is a peptide that bears no sequence homology with endogenous human thrombopoeitin, so it is not as likely to lead to neutralizing antibodies as previous peptide thrombopoeitin analogues. [9]

Heparin-induced thrombocytopenia and thrombosis (HITT)
Main article: Heparin-induced thrombocytopenia
Discontinuation of heparin is critical in a case of HITT. Beyond that, however, clinicians generally treat to avoid a thrombosis, and patients started directly on warfarin after a diagnosis of HITT are at excess risk of venous limb gangrene. For this reason, patients are usually treated with a type of blood thinner called a direct thrombin inhibitor such as the FDA-approved lepirudin or argatroban. Other blood thinners sometimes used in this setting that are not FDA-approved for treatment of HITT include bivalirudin and fondaparinux. Platelet transfusions are not a routine component of the treatment of HITT, since thrombosis, not bleeding, is the usual associated problem in this illness.

Congenital amegakaryocytic thrombocytopenia (CAMT)
Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare inherited disorder. The primary manifestations are thrombocytopenia and megakaryocytopenia, or low numbers of platelets and megakaryocytes. There is an absence of megakaryocytes in the bone marrow with no associated physical abnormalities.[10] The cause for this disorder appears to be a mutation in the gene for the TPO receptor, c-mpl, despite high levels of serum TPO.[11][12] In addition, there may be abnormalities with the central nervous system including the cerebrum and cerebellum which could cause symptoms.[11] The primary treatment for CAMT is bone marrow transplantation.
Bone Marrow/Stem Cell Transplant is the only thing that ultimately cures this genetic disease. Frequent platelet transfusions are required to keep the patient from bleeding to death until transplant is done, although this is not always the case.
One of the few non Medical Research related sources on the web with some information on CAMT is;
CAMT Specific Infant Bone Marrow Transplant Journal
There appears to be no generic resource for CAMT patients on the web, and this is potentially due to the rariety of the disease.

References
^ "Platelet count aka thrombocyte count". Lab Tests Online UK (2004-05-28). Retrieved on 2008-05-22.
^ Howard C, Adams L, Admire J, Chu M, Alred G (1997). "Vancomycin-induced thrombocytopenia: a challenge and rechallenge". Ann Pharmacother 31 (3): 315–8. PMID 9066938.
^ Von Drygalski A, Curtis BR, Bougie DW, et al (2007). "Vancomycin-induced immune thrombocytopenia". N. Engl. J. Med. 356 (9): 904–10. doi:10.1056/NEJMoa065066. PMID 17329697, http://content.nejm.org/cgi/pmidlookup?view=short&pmid=17329697&promo=ONFLNS19.
^ Furlan M, Lämmle B (2001). "Aetiology and pathogenesis of thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome: the role of von Willebrand factor-cleaving protease". Best Pract Res Clin Haematol 14 (2): 437–54. doi:10.1053/beha.2001.0142. PMID 11686108.
^ Tsai H (2003). "Advances in the pathogenesis, diagnosis, and treatment of thrombotic thrombocytopenic purpura". J Am Soc Nephrol 14 (4): 1072–81. doi:10.1097/01.ASN.0000060805.04118.4C. PMID 12660343.
^ Bussel J, Kuter D, George J, McMillan R, Aledort L, Conklin G, Lichtin A, Lyons R, Nieva J, Wasser J, Wiznitzer I, Kelly R, Chen C, Nichol J (2006). "AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP". N Engl J Med 355 (16): 1672–81. doi:10.1056/NEJMoa054626. PMID 17050891.
^ AMGEN (2008-03-12). "Press release: Amgen Statement on Successful Outcome of Romiplostim Panel Meeting", Business Wire via drugs.com. Retrieved on 22 May 2008.
^ "US FDA panel backs Amgen's Nplate against ITP", Reuters (2008-03-12). Retrieved on 22 May 2008.
^ Broudy V, Lin N (2004). "AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl". Cytokine 25 (2): 52–60. doi:10.1016/j.cyto.2003.05.001. PMID 14693160.
^ Freedman MH, Estrov Z (1990). "Congenital amegakaryocytic thrombocytopenia: an intrinsic hematopoietic stem cell defect". Am. J. Pediatr. Hematol. Oncol. 12: 225–230.
^ a b Ihara K, Ishii E, Eguchi M, Takada H, Suminoe A, Good RA, Hara T (1999). "Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia". Proc. Natl. Acad. Sci. 96: 3133–6. doi:10.1073/pnas.96.6.3132. PMID 10077649.
^ Ballmaier M, Germeshausen M, Schulze H, Cherkaoui K, Lang S, Gaudig A, Krukemeier S, Eilers M, Strauss G, Welte K (2001). "C-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia". Blood. 97: 139–46. doi:10.1182/blood.V97.1.139. PMID 11133753.

External links
11-133b. at Merck Manual of Diagnosis and Therapy Professional Edition
Thrombocytopenia Forum
[hide]
vdePathology: hematology · myeloid hematologic disease (primarily D50-D77 · 280-289)
RBCs/hemoglobinopathy
+
Polycythemia · Macrocytosis
·
Anemia
Nutritional
Iron deficiency anemia (Plummer-Vinson syndrome) · Megaloblastic anemia (Pernicious anemia)
Hemolytic
Hereditary
enzyme: G6PD Deficiency · Pyruvate kinase deficiency · Triosephosphate isomerase deficiency
hemoglobin: Thalassemia · Sickle-cell disease/traitmembrane: Hereditary spherocytosis · Hereditary elliptocytosis · Hereditary stomatocytosis
Acquired
Autoimmune (Warm, Cold) · HUS · MAHA · PNH · PCH · Myelophthisic
Aplastic
Acquired PRCA · Diamond-Blackfan anemia · Fanconi anemia · Sideroblastic anemia
Blood tests
MCV (Normocytic, Microcytic, Macrocytic) · MCHC (Normochromic, Hypochromic)
Other
Methemoglobinemia
Coagulation/platelets/coagulopathy/bleeding diathesis
+
Hypercoagulability
primary: Antithrombin III deficiency · Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden · Hyperprothrombinemiaacquired: DIC (Congenital afibrinogenemia, Purpura fulminans) · autoimmune (Antiphospholipid)
Other
Essential thrombocytosis
·
clotting factor: Hemophilia (A/VIII, B/IX, C/XI) • Von Willebrand diseaseHypoprothrombinemia/II · XIII
platelet function: Bernard-Soulier syndrome · Glanzmann's thrombasthenia · Hermansky-Pudlak syndrome · Gray platelet syndrome · May Hegglin anomaly · Pelger-Huet anomaly
Purpura: Henoch-Schönlein · TP · ITP (Evans syndrome) · TTPThrombocytopenia (Heparin-induced thrombocytopenia)
Monocytes/macrophages
+
Histiocytosis
WHO-I (Langerhans cell histiocytosis)
WHO-II/non-Langerhans-cell (Juvenile xanthogranuloma, Hemophagocytic lymphohistiocytosis)WHO-III/malignant (Acute monocytic leukemia, Malignant histiocytosis, Erdheim-Chester disease)
Other
Chronic granulomatous disease-cytosis: Monocytosis
·
-penia: Monocytopenia
Granulocytes
+
-cytosis: granulocytosis (Neutrophilia, Eosinophilia, Basophilia)
·
-penia: Granulocytopenia/agranulocytosis (Neutropenia/Kostmann syndrome · Eosinopenia · Basopenia)
See also hematological malignancy and immune disorders

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